Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis
Nguyen Dinh Luyen
Le Mai Huong
Tran Thi Hong Ha
Le Huu Cuong
Duong Thi Hai Yen
Nguyen Xuan Nhiem
Bui Huu Tai
Astrid Gärdes
German Kopprio
Phan Van Kiem
Abstract
Chemical investigation of the Kappaphycus alvarezii-derived endophytic fungus Aspergillus micronesiensis lead to the isolation of three novel dibenzospiroketals, aspermicrones A-C (1-3). Their chemical structures were determined by extensive analysis of HR-ESI-MS and NMR spectral data. The absolute configurations of them were determined by experimental and TD-DFT theoretical calculated circular dichroism spectra. Compound 2 exhibited selective cytotoxic effect toward HepG2 cell line (IC50 = 9.9 µM). Additionally, both of compounds 2 and 3 displayed anti-microbial activity against Staphylococcus aureus (MIC = 123.2 µM for each compound). Compound 1 was inactivity in both cytotoxic and anti-microbial assays.
Luyen N.D., Huong L.M., Thi Hong Ha T., Cuong L.H., Thi Hai Yen D., Nhiem N.X., Tai B.H., Gärdes A., Kopprio G. and Van Kiem P. (2019) Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis. The Journal of Antibiotics 72(11): 843-847. 10.1038/s41429-019-0214-8
@article{Luyen2019,
Title = {Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis},
Author = {Luyen, Nguyen Dinh and Huong, Le Mai and Thi Hong Ha, Tran and Cuong, Le Huu and Thi Hai Yen, Duong and Nhiem, Nguyen Xuan and Tai, Bui Huu and Gärdes, Astrid and Kopprio, German and Van Kiem, Phan},
Editor = {},
Journal = {The Journal of Antibiotics},
Year = {2019},
Pages = {843-847},
Volume = {72},
Doi = {10.1038/s41429-019-0214-8},
Abstract = {Chemical investigation of the Kappaphycus alvarezii-derived endophytic fungus Aspergillus micronesiensis lead to the isolation of three novel dibenzospiroketals, aspermicrones A-C (1-3). Their chemical structures were determined by extensive analysis of HR-ESI-MS and NMR spectral data. The absolute configurations of them were determined by experimental and TD-DFT theoretical calculated circular dichroism spectra. Compound 2 exhibited selective cytotoxic effect toward HepG2 cell line (IC50 = 9.9 µM). Additionally, both of compounds 2 and 3 displayed anti-microbial activity against Staphylococcus aureus (MIC = 123.2 µM for each compound). Compound 1 was inactivity in both cytotoxic and anti-microbial assays.},
}
TY - JOUR
AU - Luyen, Nguyen Dinh
AU - Huong, Le Mai
AU - Thi Hong Ha, Tran
AU - Cuong, Le Huu
AU - Thi Hai Yen, Duong
AU - Nhiem, Nguyen Xuan
AU - Tai, Bui Huu
AU - Gärdes, Astrid
AU - Kopprio, German
AU - Van Kiem, Phan
TI - Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis
T2 - The Journal of Antibiotics
PY - 2019
SP - 843-847
VL - 72
DO - 10.1038/s41429-019-0214-8
AB - Chemical investigation of the Kappaphycus alvarezii-derived endophytic fungus Aspergillus micronesiensis lead to the isolation of three novel dibenzospiroketals, aspermicrones A-C (1-3). Their chemical structures were determined by extensive analysis of HR-ESI-MS and NMR spectral data. The absolute configurations of them were determined by experimental and TD-DFT theoretical calculated circular dichroism spectra. Compound 2 exhibited selective cytotoxic effect toward HepG2 cell line (IC50 = 9.9 µM). Additionally, both of compounds 2 and 3 displayed anti-microbial activity against Staphylococcus aureus (MIC = 123.2 µM for each compound). Compound 1 was inactivity in both cytotoxic and anti-microbial assays.
ER -
