Titanium (Ti), used in many dailyuse products, such as shampoos and sunscreen filters, in the form of TiO2 nanoparticles (NPs), may elicit adverse marine biota effects. Marine mammal Ti data is scarce, and subcellular distribution and detoxification information is non-existent. Ti concentrations and metalloprotein detoxification in Pontoporia blainvillei and Steno bredanensis dolphins from Southeastern Brazil were assessed. Metallothionein (MT) concentrations were determined spectrophotometrically, total and subcellular Ti, by ICP-MS and detoxification, by HPLC-ICP-MS. Ti detoxification occurred through MT complexation. Statistical Ti-MT associations were observed in S. bredanensis liver, indicating TiO2 NPs contamination, as Ti binds to MT only as NPs. MT-Ti correlations were observed for both the coastal (P. blainvillei) and offshore (S. bredanensis) dolphins, evidencing oceanic TiO2 diffusion. Ti detoxification through binding to reduced glutathione occurred in both species. Thermostable subcellular fractions are a valuable tool for cetacean Ti detoxification assessments and should be applied to conservation efforts.
Monteiro F., Lemos L.S., de Moura J.F., Rocha R.C.C., Moreira I., Di Beneditto A.P.M., Kehrig H.A., Bordon I.C., Siciliano S., Saint'Pierre T.D. and Hauser-Davis R.A. (2020) Total and subcellular Ti distribution and detoxification processes in Pontoporia blainvillei and Steno bredanensis dolphins from Southeastern Brazil. Marine Pollution Bulletin 153: 110975. 10.1016/j.marpolbul.2020.110975[Online ahead of print]
@article{Monteiro2020,
Title = {Total and subcellular Ti distribution and detoxification processes in Pontoporia blainvillei and Steno bredanensis dolphins from Southeastern Brazil},
Author = {Monteiro, Fernanda and Lemos, Leila S. and de Moura, Jailson Fulgencio and Rocha, Rafael Christian Chávez and Moreira, Isabel and Di Beneditto, Ana Paula M. and Kehrig, Helena A. and Bordon, Isabella C. and Siciliano, Salvatore and Saint'Pierre, Tatiana D. and Hauser-Davis, Rachel Ann},
Editor = {},
Journal = {Marine Pollution Bulletin},
Year = {2020},
Pages = {110975},
Volume = {153},
Doi = {10.1016/j.marpolbul.2020.110975},
Abstract = {Titanium (Ti), used in many dailyuse products, such as shampoos and sunscreen filters, in the form of TiO2 nanoparticles (NPs), may elicit adverse marine biota effects. Marine mammal Ti data is scarce, and subcellular distribution and detoxification information is non-existent. Ti concentrations and metalloprotein detoxification in Pontoporia blainvillei and Steno bredanensis dolphins from Southeastern Brazil were assessed. Metallothionein (MT) concentrations were determined spectrophotometrically, total and subcellular Ti, by ICP-MS and detoxification, by HPLC-ICP-MS. Ti detoxification occurred through MT complexation. Statistical Ti-MT associations were observed in S. bredanensis liver, indicating TiO2 NPs contamination, as Ti binds to MT only as NPs. MT-Ti correlations were observed for both the coastal (P. blainvillei) and offshore (S. bredanensis) dolphins, evidencing oceanic TiO2 diffusion. Ti detoxification through binding to reduced glutathione occurred in both species. Thermostable subcellular fractions are a valuable tool for cetacean Ti detoxification assessments and should be applied to conservation efforts.},
}
TY - JOUR
AU - Monteiro, Fernanda
AU - Lemos, Leila S.
AU - de Moura, Jailson Fulgencio
AU - Rocha, Rafael Christian Chávez
AU - Moreira, Isabel
AU - Di Beneditto, Ana Paula M.
AU - Kehrig, Helena A.
AU - Bordon, Isabella C.
AU - Siciliano, Salvatore
AU - Saint'Pierre, Tatiana D.
AU - Hauser-Davis, Rachel Ann
TI - Total and subcellular Ti distribution and detoxification processes in Pontoporia blainvillei and Steno bredanensis dolphins from Southeastern Brazil
T2 - Marine Pollution Bulletin
PY - 2020
SP - 110975
VL - 153
DO - 10.1016/j.marpolbul.2020.110975
AB - Titanium (Ti), used in many dailyuse products, such as shampoos and sunscreen filters, in the form of TiO2 nanoparticles (NPs), may elicit adverse marine biota effects. Marine mammal Ti data is scarce, and subcellular distribution and detoxification information is non-existent. Ti concentrations and metalloprotein detoxification in Pontoporia blainvillei and Steno bredanensis dolphins from Southeastern Brazil were assessed. Metallothionein (MT) concentrations were determined spectrophotometrically, total and subcellular Ti, by ICP-MS and detoxification, by HPLC-ICP-MS. Ti detoxification occurred through MT complexation. Statistical Ti-MT associations were observed in S. bredanensis liver, indicating TiO2 NPs contamination, as Ti binds to MT only as NPs. MT-Ti correlations were observed for both the coastal (P. blainvillei) and offshore (S. bredanensis) dolphins, evidencing oceanic TiO2 diffusion. Ti detoxification through binding to reduced glutathione occurred in both species. Thermostable subcellular fractions are a valuable tool for cetacean Ti detoxification assessments and should be applied to conservation efforts.
ER -
