The marine sponge Dysidea herbacea collected from Indonesia yielded four new polybrominated diphenyl ether congeners 2−5 and the known derivatives 1, 6, and 7. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long-range 13C− 1H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the Gram-positive bacteria Bacillus subtilis and the phytopathogenic fungus Cladosporium cucumerinum. The isolated polybrominated compounds were also active in the brine shrimp lethality test. In the latter bioassay, compounds 1 and 6 were the most active with LC50's of 0.96 [SE ± 0.19] and 0.94 [SE ± 0.70] μg/mL, respectively.
Handayani D., Edrada R.A., Proksch P., Wray V., Witte L., Van Soest R.W.M., Kunzmann A. and Soedarsono (1997) Four New Bioactive Polybrominated Diphenyl Ethers of the SpongeDysidea herbaceafrom West Sumatra, Indonesia. Journal of Natural Products 60(12): 1313-1316. 10.1021/np970271w
@article{Handayani1997,
Title = {Four New Bioactive Polybrominated Diphenyl Ethers of the SpongeDysidea herbaceafrom West Sumatra, Indonesia},
Author = {Handayani, Dian and Edrada, Ru Angelie and Proksch, Peter and Wray, Victor and Witte, Ludger and Van Soest, Rob W. M. and Kunzmann, Andreas and Soedarsono},
Editor = {},
Journal = {Journal of Natural Products},
Year = {1997},
Pages = {1313-1316},
Volume = {60},
Doi = {10.1021/np970271w},
Abstract = {The marine sponge Dysidea herbacea collected from Indonesia yielded four new polybrominated diphenyl ether congeners 2−5 and the known derivatives 1, 6, and 7. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long-range 13C− 1H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the Gram-positive bacteria Bacillus subtilis and the phytopathogenic fungus Cladosporium cucumerinum. The isolated polybrominated compounds were also active in the brine shrimp lethality test. In the latter bioassay, compounds 1 and 6 were the most active with LC50's of 0.96 [SE ± 0.19] and 0.94 [SE ± 0.70] μg/mL, respectively.},
}
TY - JOUR
AU - Handayani, Dian
AU - Edrada, Ru Angelie
AU - Proksch, Peter
AU - Wray, Victor
AU - Witte, Ludger
AU - Van Soest, Rob W. M.
AU - Kunzmann, Andreas
AU - Soedarsono
TI - Four New Bioactive Polybrominated Diphenyl Ethers of the SpongeDysidea herbaceafrom West Sumatra, Indonesia
T2 - Journal of Natural Products
PY - 1997
SP - 1313-1316
VL - 60
DO - 10.1021/np970271w
AB - The marine sponge Dysidea herbacea collected from Indonesia yielded four new polybrominated diphenyl ether congeners 2−5 and the known derivatives 1, 6, and 7. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long-range 13C− 1H correlations) and mass spectrometric (EIMS) data. All of the compounds were active against the Gram-positive bacteria Bacillus subtilis and the phytopathogenic fungus Cladosporium cucumerinum. The isolated polybrominated compounds were also active in the brine shrimp lethality test. In the latter bioassay, compounds 1 and 6 were the most active with LC50's of 0.96 [SE ± 0.19] and 0.94 [SE ± 0.70] μg/mL, respectively.
ER -
